Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1), can degrade a broad range of substrates including collagen alpha chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro MMP-1, pro MMP-7, pro MMP-8, pro MMP-9 and pro MMP-13. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. Product Properties Synonyms Matrix Metalloproteinase-3, Stromelysin-1, SL-1, Transin-1 Uniprot No. P08254 Source Recombinant Human MMP-3 Protein is expressed from E.coli with His tag at the C-terminal. It contains Arg101-Cys477. Molecular Weight Approximately 42.8 kDa. Purity > 95% as determined by SDS-PAGE. Endotoxin
