The epidermal growth factor receptor (EGFR) subfamily of receptor tyrosine kinases comprises four members: EGFR (HER1), ErbB2, ErbB3, and ErbB4. EGFRVIII is tumor specific, and has not been found in normal tissues. EGFRvIII is highly tumorigenic, and can cause aggressive tumor phenotype, with increased invasion, proliferation, angiogenesis, and evasion of apoptosis. Specifications Synonyms ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2 Uniprot No. NP_001333870 Source Recombinant Human EGFRVIII Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu25-Ser378. Molecular Weight The protein has a predicted MW of 40.28 kDa. And it migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Purity > 95% as determined by SDS-PAGE. Endotoxin
