The EGFR subfamily of receptor tyrosine kinases comprises four members: EGFR ( HER-1), ErbB2, ErbB3, and ErbB4. EGFR binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, and epigen . Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, heterodimerization tyrosine phosphorylation and cell signaling. Specifications Synonyms ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2 Uniprot No. P00533-1 Source Recombinant FITC-Labeled Human EGFR/HER1 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Leu25-Ser645. Molecular Weight The protein has a predicted MW of 71.5 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGE. Endotoxin < 1.0 EU per 1μg of the protein by the LAL method. Formulation Supplied as 0.22μm filtered solution in PBS (pH 7.4). Storage The products are shipped with ice pack and can be stored at -80℃ for 1 year. Recommend to aliquot the protein into smaller quantities for optimal Storage. Please avoid freeze-thaw cycles. Note 1. For your safety and health, please wear lab coats and disposable gloves for operation. 2. For research use only! Product Data
