Her3(Human epidermal growth factor Receptor 3), belongs to the protein kinase superfamily, the tyr protein kinase family, and the EGF receptor subfamily. This membrane-bound glycoprotein has a neuregulin-binding domain but no active kinase domain. It does not mediate intracellular signal transduction through protein phosphorylation, but can form heterodimerers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to generate receptor complexes and initiate pathways that lead to cell proliferation or differentiation. Specifications Synonyms ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; ERBB3 Uniprot No. P21860 Source Recombinant Human HER3 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Ser20-Thr643. Molecular Weight The protein has a predicted MW of 70.6 kDa. And it migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Purity > 95% as determined by SDS-PAGE. Concentration 1mg/mL Endotoxin
