C-type lectin domain family 7 member A (Clec7a, or Dectin-1) is a transmembrane protein containing an intracellular immunoreceptor tyrosine-based activation (ITAM)-like motif and an extracellular C-type lectin-like domain for recognition. Clec7a is expressed by macrophages and some other immune cells and is believed to control the innate immune responses to pathogens and the phagocytotic properties, through regulating phagocytosis and production of reactive oxygen species (ROS). Moreover, a recent study has shown that Clec7a is critical for macrophage polarization during renal interstitial fibrosis. Product Information Product Information. Catalog Number Size Recombinant Human CLEC7A Protein,hFc Tag 96588ES60 100 μg 96588ES76 500 μg Product Properties Synonyms BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2 Species Human Expression Sequence Thr66-Met247,with C-terminal Human IgG Fc Accession Q9BXN2 Tag C-hFc Tag Expression System HEK293 Molecular Weight 55-72kDa (Reducing) Purity > 95% as determined by SDS-PAGE. Endotoxin < 0.1 EU/μg Formulation PBS, pH7.4. Appearance Lyophilized Powder Reconstitution Method Reconstitute at 0.1-1 mg/mL according to the size in ultrapure water after rapid centrifugation. Product Features High activity, high purity, low endotoxin, high lot-to-lot consistency Storage Store at -25 ~ -15°C, valid for 1 year after receipt. After reconstitution, store at 2~8°C under sterile conditions, valid for 7 days. After reconstitution, store at -85 ~ -65°C under sterile conditions, valid for 3 months. Documents: Manuals 96588_Manual_HB20260421
