Thrombopoietin (Tpo), is a key regulator of megakaryocytopoiesis and thrombopoiesis.TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Specification Synonyms Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF Uniprot No. P40226 Source Mouse TPO Protein is expressed from HEK293 without tag. It contains Ser22-Thr356. Molecular Weight The protein has a predicted 35.6 kDa Purity > 95% as determined by SDS-PAGE. Biological Activity Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The EC50 for this effect is 0.04-2.4 ng/mL. Endotoxin < 0.01 EU per 1 μg of the protein by the LAL method. Formulation Dissolved in sterile PBS buffer. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. Storage The product should be stored at -85~-65℃ for 1 year from date of receipt. Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles. Caution 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
